To date, 29 March 2023, according to WHO, 761,402,282 cases of SARS-CoV-2 infection have been confirmed, and 6,887,000 deaths have been reported due to COVID-19. The coronavirus disease 2019 (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2) which was declared a Public Health Emergency of International Concern by the World Health Organization (WHO) on 30 January 2020. The COVID-19 Pandemic in Global Perspective Vitamin D 3 supplementation can potentially support disease-mitigation in acute and long COVID-19. Vitamin D 3’s biological effects can provide protection and repair in multiple organ systems affected by SARS-CoV-2. Higher doses of vitamin D 3 supplementation may improve health and survivorship in individuals of various age groups, comorbidities, and severity of disease symptoms. Recent FindingsĮpidemiological studies have shown that individuals who were deficient in vitamin D 3 had worse COVID-19 health outcomes and mortality rates. The review proposes vitamin D 3 as a plausible molecule for prevention, protection, and disease mitigation of acute and long COVID-19. While vaccinations support the fight against SARS-CoV-2, other effective mechanisms of population protection should exist given the presence of yet unvaccinated and at-risk vulnerable groups, global disease comorbidities, and short-lived vaccine responses. Long-term physiological and psychological symptoms, known as long COVID-19, persist affecting multiple organ systems. COVID-19 caused by the infectious severe acute respiratory syndrome coronavirus (SARS-CoV-2) has acute respiratory and cardiometabolic symptoms that can be severe and lethal. The coronavirus disease 2019 (COVID-19) pandemic has challenged global health systems and economies from January 2020.
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